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Introduction: The Very Low-Density Lipoprotein Cholesterol (VLDL-C) test is part of a lipid profile, a group of tests used to assess the risk of developing heart disease. VLDL is one of the four major lipoprotein particles circulating in the blood, with the others being high-density lipoprotein (HDL), low-density lipoprotein (LDL) and chylomicrons. VLDL particles are involved in transporting triglycerides, cholesterol and proteins throughout the body.
Test Sample: A blood sample is drawn from a vein in the arm or obtained by puncturing the skin on a fingertip. Fasting for 9-12 hours before the test is recommended (only water permitted) and alcohol should be avoided for 24 hours before the test.
How It’s Used: VLDL-C is not typically measured directly but is estimated based on triglyceride levels. The test is often reported as part of a lipid profile, providing information about an individual’s risk of coronary heart disease. Elevated VLDL-C levels (>30 mg/dL) are considered a risk factor for heart disease and stroke. High VLDL levels, along with high LDL levels, may influence treatment decisions.
When It’s Ordered: VLDL-C is not usually ordered as a separate test. It is reported when a lipid profile is conducted to assess heart disease risk.
Interpreting Results: An elevated VLDL-C level, like high LDL cholesterol, is a risk factor for heart disease. The presence of high VLDL, along with high LDL, may affect the choice of cholesterol-lowering therapies, including lifestyle changes and medications. Low VLDL-C levels are not generally a concern.
Additional Information:
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